The Lab of Adaptive Immunity was established by Ondřej Štěpánek in 2016. Our research group works at the Institute of Molecular Genetics (Prague, Czech Republic) which is one out of more than 50 institutes of the Czech Academy of Sciences. We elucidate how T cells make the proper fate decisions to elicit a potent immune protection and maintain self-tolerance at the same time. Our current research projects focus on the mechanisms of T-cell signaling via antigenic and germ-line encoded receptors, characterization of particular T-cell subsets, and mechanisms of signaling induced by a prominent T-cell cytokine, IL-17. Moreover, we study the biology of a protein complex called BBSome in immune cells and ciliated cells, to understand a rare disease called Bardet-Biedl Syndrome.