Currently, we do not have any open positions.
Open position for a PhD student:
T-cell signaling in models of human diseases
Project Title: T-cell signaling in models of human diseases
Supervisor: Ondřej Štěpánek
T cells represent the adaptive arm of immunity against infections and cancers. However, T cells also induce autoimmune diseases when they lose self-tolerance. The key to the biology of T-cells is their unique antigen receptor, which discriminates self and non-self antigens. Moreover, additional receptors and signaling pathways modulate T-cell fate decisions. The student will discover novel mechanisms in key T-cell signaling pathways and investigate their importance in established animal models of infection, cancer, and autoimmunity. The Lab of Adaptive Immunity offers a productive and stimulating environment (see our recent publications). We have established multiple national and international collaborations and we are well supported by domestic and international research grants. Our lab is the first and only immunological research group with an ERC grant in the country.
We are looking for highly motivated and smart candidates with a master degree in immunology, cell biology, molecular biology, biochemistry, medicine or a related field. The candidate must be able to communicate in English. Additional skills and experience (wet lab, coding, languages etc.) are appreciated but not essential. If you want to make a huge step towards your successful career in life sciences, get great theoretical and practical skills, and finish your PhD with a decent research paper in a timely manner, do not hesitate to apply! The student will receive 24,000 CZK salary plus a non-taxable stipend of 10,500 CZK per month. The candidates are strongly encouraged to contact the PI, Ondrej Stepanek, directly.
- Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells. Horkova V, Drobek A, Mueller D, Gubser C, Niederlova V, Wyss L, King CG, Zehn D, Stepanek O. Cell Rep. 2020 Feb 4;30(5):1504-1514.e7.
- Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells. Drobek A, Moudra A, Mueller D, Huranova M, Horkova V, Pribikova M, Ivanek R, Oberle S, Zehn D, McCoy KD, Draber P, Stepanek O. EMBO J. 2018 Jul 13;37(14):e98518. doi: 10.15252/embj.201798518.
- Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, Naeher D, Beaufils-Hugot M, Abanto ML, Galati V, Hausmann B, Lang R, Cole DK, Huseby ES, Sewell AK, Chakraborty AK, Palmer E. Cell. 2014 Oct 9;159(2):333-45. doi: 10.1016/j.cell.2014.08.042.
We welcome motivated researchers at any career stages
If you are interested in joining the lab, please send an e-mail to firstname.lastname@example.org. Include your CV and a motivation letter explaining the reasons why you want to join the Group of Adaptive Immunity and why we should take you on board.
Please note that inquiries without the CV and a personalized motivation letter (such as generic job application) will not be considered.