Our lab has 2 open PhD positions:
Project Title: Mapping T-cell functions using single cell transcriptomics
Supervisor: Ondřej Štěpánek
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Project Description:
The group of Adaptive Immunity has a strong publication record in the field of T-cell biology. Recently, we have introduced single cell RNA transcriptomics and analysis of antigenic receptors to uncover and characterize novel T-cell subsets, including their antigenic specificity. Within the project, the student will analyze unique single T-cell data (transcriptomics, ATACseq, repertoire) from animal models of immunological diseases (infection, cancer, autoimmunity) and/or human patients. Moreover, the student will develop novel tools for these analyses. The inclusion of experimental wet work in this project is optional, depending on the preferences and background of the selected candidate.
We offer high scientific standards in the amazing field of T-cell-mediated immunity and the environment of a young, but experienced, lab. The student with receive full time salary according to IMG standards and the stipend from the affiliated university.
Candidate Profile:
We are looking for an enthusiastic early career scientist who wants to use their programming skills to tackle biological problems in our multidisciplinary team. The candidate should show high level of independence and problem solving skills in programming/bioinformatics. However, they should be able to collaborate with experimental scientists within our interdisciplinary team as well.
The successful candidate has a master’s degree (or is close to its completion) in bioinformatics, computational science, biological, or chemical sciences. The candidate should have the prior experience with the analysis of large biological data and/or computational modeling of biological processes.
Only candidates, who directly contact the PI (ondrej.stepanek@img.cas.cz) before 28.2.2022 will be considered for the interviews.
Suggested reading:
- https://www.biorxiv.org/content/10.1101/2021.11.10.467495v2
- https://www.embopress.org/doi/full/10.15252/embj.201798518
- https://adaptiveimmunity.img.cas.cz/publications/
Project Title: Protective and pathological tissue-infiltrating T-cells in infections
Supervisor: Ondřej Štěpánek
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Project Description:
The group of Adaptive Immunity has a strong publication record in the field of T-cell biology. One of our long-term interests is uncovering the diversity of T-cell subsets with unique functions. This PhD project in experimental immunology focuses on the tissue infiltrating protective T cells (e.g., tissue resident memory T cells) and pathogenic T cells inducing damage to host tissues, which arise during bacterial and viral infections. The student will use the state-of-the-art methods (scRNAseq, mouse models of infection, flow cytometry) to characterize T-cells in tissues. In the next step, they will analyze the biological role of these subsets using our model systems for generating monoclonal T-cells.
We offer high scientific standards in the amazing field of T-cell-mediated immunity and the environment of a young, but experienced, lab. The student with receive full time salary according to IMG standards and the stipend from the affiliated university.
Candidate Profile:
We are looking for an enthusiastic early career scientist who wants to tackle the fundamental roles of T cells in infections. The candidate should show high level of problem solving skills and the ability to collaborate within our interdisciplinary team.
The successful candidate has a master’s degree (or is close to its completion) in life-sciences. Prior experience with experimental lab work is required (e.g., within a master’s diploma research project).
Only candidates, who contact the PI (ondrej.stepanek@img.cas.cz) directly before 28.2.2022 will be considered for the interviews.
Suggested reading:
- https://www.biorxiv.org/content/10.1101/2021.11.10.467495v2
- https://www.embopress.org/doi/full/10.15252/embj.201798518
- https://adaptiveimmunity.img.cas.cz/publications/
We welcome motivated researchers at any career stages
If you are interested in joining the lab, please send an e-mail to ondrej.stepanek@img.cas.cz. Include your CV and a motivation letter explaining the reasons why you want to join the Group of Adaptive Immunity and why we should take you on board.
Please note that inquiries without the CV and a personalized motivation letter (such as generic job application) will not be considered.